Personalized Problem Sets effort led by Julia Khodor and Michelle Mischke Personalized problem sets are one of the mechanisms we proposed to try to give students in large lecture courses some of the sense of personal involvement they experience in small advanced research lab courses. In our first experiment concerning this idea, we designed two personalized problem sets for 7.014 this past spring semester. Since the students did not all have same gene or protein, they could collaborate but not copy. Furthermore, there was continuity between the problem sets so they could follow the gene to the protein. The results were encouraging enough that we plan to try it again in a modified form this coming spring.